How to rule a gene galaxy: A lesson from developing neurons

first_img“Coherent regulation of multiple genes can pose substantial logistical problems, akin running a successful business employing thousands of people or controlling the vast Galactic Empire from the Star Wars movies” remarks Dr. Eugene Makeyev, a senior author of the study from the MRC CDN. “Our work suggests that fine-tuning messenger stability is an important mechanism orchestrating gene expression changes during normal brain development”.Defective regulation of messenger stability, cellular localization and translation into corresponding protein products often leads to serious medical conditions including neurodegenerative diseases and cancer. A subset of the TTP/miR-9 target genes have been previously linked to these disorders and it will be important to determine whether deregulation of TTP or/and miR-9 plays a causative role in such pathological contexts.Moreover, by uncovering a hitherto unknown mechanism mediating neuronal differentiation, the study by Makeyev and co-authors should facilitate development of novel cell replacement therapies for neurological and neurodegenerative diseases. “Natural renewal of neurons in the adult brain is notoriously inefficient and it likely becomes virtually non-existent as we grow older. With a continued increase in the average life expectancy neuron replacement might become a common medical procedure at some point in the future. Luke Skywalker and his aging father would certainly relate to this idea”. LinkedIn Email Share The human organism contains hundreds of distinct cell types that often differ from their neighbours in shape and function. To acquire and maintain its characteristic features, each cell type must express a unique subset of genes. Neurons, the functional units of our brain, develop through differentiation of neuronal precursors, a process that depends on coordinated activation of hundreds and possibly thousands of neuron-specific genes.A new study published in Nature Communications by researchers from the MRC Centre for Developmental Neurobiology (MRC CDN) at IoPPN, carried out in collaboration with the Tian lab at the Rutgers New Jersey Medical School (USA), unravels how this synchrony is achieved at the molecular level. The researchers found that many RNA messengers encoding neuronal proteins contain specialized sequences that can promote their destabilization in the presence of an RNA-binding protein called tristetraprolin, or TTP.This protein is expressed at relatively high levels in proliferating precursors and non-neuronal cells but down-regulated in developing neurons by a brain-enriched regulatory RNA called miR-9. The TTP/miR-9 pair functions as a switch limiting unscheduled accumulation of neuronal messengers in non-neuronal cells and ensuring coordinated accumulation of these molecules in neurons.center_img Share on Facebook Pinterest Share on Twitterlast_img read more

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Emerson acquires Advanced Engineering Valves

first_imgSubscribe Get instant access to must-read content today!To access hundreds of features, subscribe today! At a time when the world is forced to go digital more than ever before just to stay connected, discover the in-depth content our subscribers receive every month by subscribing to gasworld.Don’t just stay connected, stay at the forefront – join gasworld and become a subscriber to access all of our must-read content online from just $270.last_img

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Knocking an opportunity

first_imgSubscribe to Building today and you will benefit from:Unlimited access to all stories including expert analysis and comment from industry leadersOur league tables, cost models and economics dataOur online archive of over 10,000 articlesBuilding magazine digital editionsBuilding magazine print editionsPrinted/digital supplementsSubscribe now for unlimited access.View our subscription options and join our community Subscribe now for unlimited access Get your free guest access  SIGN UP TODAY To continue enjoying Building.co.uk, sign up for free guest accessExisting subscriber? LOGIN Stay at the forefront of thought leadership with news and analysis from award-winning journalists. Enjoy company features, CEO interviews, architectural reviews, technical project know-how and the latest innovations.Limited access to building.co.ukBreaking industry news as it happensBreaking, daily and weekly e-newsletterslast_img read more

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Woman whose daughter was threatened with custody by judge has convictions quashed

first_imgA woman deprived of a fair hearing through the conduct of a trial judge has had her convictions overturned by the Court of Appeal.The court ruled that His Honour Judge Stephen John had unfairly made comments during the woman’s trial which indicated his belief in her guilt.He had urged her counsel to give ‘robust advice’ about her plea and withdrew the woman’s bail and remanded her in custody the night before she was due to give evidence. He also threatened her 14-year-old daughter with custody if the teenager made any facial response to the testimony that was being given. This meant the woman doubted the fairness of the process and was thereby ‘handicapped’ in giving her evidence.The woman was convicted at Kingston Crown Court in April of bringing cannabis, two mobile phones, two charging cables and a SIM card on a visit to her partner in prison. The handover had allegedly happened while she visited the prisoner with her teenage daughter. A search of the prisoner later revealed he had stashed these items on his person. The woman, who was jailed for 18 months, admitted smuggling in the SIM card but denied being responsible for the other items. In the appeal, her lawyers argued the judge’s decision to hold her on remand overnight demonstrated a ‘hostile attitude’ and affected the quality of her evidence. They submitted that when the woman gave evidence, the judge posed questions more akin to comment or cross-examination than attempts at clarification. HHJ John had already directed that the woman’s teenage daughter sit at the back of the courtroom and not approach the dock. He warned the 14-year-old that if she responded in any way during the evidence, he would ‘have the officer arrest you and take you downstairs. And I don’t care if you’re 14; you’ll go into a cell same as anybody else.’ When defence barrister Michael Haggar sought to intervene, the judge replied: ‘Don’t lecture me Mr Hadder [sic], I’m speaking to her.’ The Court of Appeal said it was not appropriate for the judge to threaten the girl with custody at all – let alone for a facial reaction to the evidence. If he wanted to restrict her input, he could simply have not allowed her in the courtoom. Appeal judges found substance in four grounds of complaint, which taken together led the woman to think he had taken an adverse view of her case and that she would not get a fair trial.  This may well have handicapped her in giving evidence and resulted in her not receiving a fair trial. The conviction was set aside and the prosecution opted not to seek a retrial.,Supporting documents Click link to download and view these files MyersPDF, Size 0.16 mblast_img read more

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Egyptian government slams media reports on Italian student’s death

first_imgEgypt’s interior ministry has slammed media report that claim the slain Italian student Guilio Regeni died in police custody.The Reuters news agency is citing several intelligence and police sources.But the ministry says that report is unfounded.Regeni went missing in Cairo in January. His body was found days later in a ditch. The corpse showed signs of extensive torture.Earlier this month President Abdel Fattah El Sisi dismissed claims that security forces were involved in his death.Instead, he blamed evil elements in Egyptian society. Italian police have been urging Cairo to share more information relating to the case.last_img read more

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Wow Wow on brink of Series history

first_imgGARY Subratie has sights on a Boxing Day double, a WOW WOW romp in the Jamaica Two-Year-Old Stakes, which should make the bay colt the first horse to bag the $1-million bonus for sweeping the Supreme Ventures Limited Jamaica Two-Year-Old Series, which, along with the purse, would effectively hand his owner, Michros, his first owner’s title.Unbeaten in seven races after losing on debut, WOW WOW will chase history, some time after 1:30 p.m. in the third event on the nine-race Boxing Day card. Wayne DaCosta’s FEARLESS CHAMPION, who was five and a half lengths behind WOW WOW in last month’s Pick-3 Super Challenge, at seven furlongs, should again be the exacta horse.Subratie’s SENTIENT will start favourite in the eighth event at seven and a half furlongs. Tread carefully, though SENTIENT, on paper, appears to be the horse to beat after being cut down by a flying PRINCESS AVA at a mile two Saturdays ago, losing by two and three-quarter lengths in a fast-run 1:37.3.SENTIENT reported with one easy gallop, 1:10.1 for five and a half, the last five in 1:03.0, with what appeared to be vet wraps on all four, a little over a month after placing fourth in the November 9 Diamond Mile.Prepping for Thursday’s race, SENTIENT still hasn’t been asked a serious question at exercise, some six and a half weeks after the Diamond Mile, for which he had contrastingly warmed up with a zippy 1:06.1 for five and a half furlongs.Richard Azan’s DUKE might appear a tempting backup horse after closing for second behind speedy TREVOR’S CHOICE at five and a half furlongs a week ago, clearly needing more real estate. However, running on at five and a half, past tiring sprinters, doesn’t translate to beating middle-distance runners at seven and a half furlongs.Should SENTIENT, now fitted with a visor, replacing blinkers, falter again in the stretch run, Anthony Nunes’ TRICKY ONE, PRINCESS AVA’s stablemate, who was only three-quarter length behind him in third place at a mile, could be the spoiler, although carrying topweight 126lb. ainsley.walters@gleanerjm.com Due to circumstances beyond our control, we are unable to publish the Supreme Ventures Racing and Entertainment Limited tipster competition, tipster standings, and today’s final programme. We apologise for any inconvenience this has caused.last_img read more

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Bristol Sport TV – Featuring Korey Smith

first_imgAlso on this week’s show:Highlights and reaction from Bristol Rugby’s 16-21 victory over London ScottishBristol Flyers fool fans into thinking Bristol City defender Aden Flint had signed for the club on April Fools’ day.Dino Zamparelli reflects on a win and another podium finish in the 2016 Porsche Carrera Cup opening round at Brands HatchThere’s an exclusive interview with Jack Taylor of Gloucestershire Cricket who discusses plans for the season aheadAn update on the latest Ashton Gate Stadium redevelopment, as seating installation begins on the upper tier of the West StandNever miss another episode, click here to subscribe to Bristol Sport TV on YouTube.last_img read more

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USC Baseball Coach Gets Extension

first_imgColumbia, SC (WLTX) – University of South Carolina Baseball Coach Chad Holbrook has gotten a two-year contract extension.The Board of Trustees approved the deal that will keep Holbrook as the leader of the team through the 2019 season.“I want to thank the Board of Trustees, Dr. Pastides and Coach Tanner for their unwavering commitment to the entire Gamecock baseball program and me,” Holbrook said in a statement. “It is really neat and comforting to be surrounded by such great leadership. South Carolina is a special place with the best fans in the country and I am fortunate to work with an incredible staff and a group of great players that continue to represent this university the right way. We look forward to getting back out on the field soon and are excited for the upcoming season and the years ahead.”Holbrook has coached the Gamecocks for three seasons since taking over for Ray Tanner, who left the job to become USC’s Athletics Director. In that time he’s led the team to three straight playoff appearances and a .696 winning percentage, the second-highest win margin over the first two seasons of any coach in school history.Last year the Gamecocks were 44-18, with an 18-12 mark in SEC play. The team set an all-time attendance record at home last season of 305,564, during the campaign.last_img read more

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Jennifer Hudson dishes on former co-stars in November issue of “Cosmopolitan”

first_imgABC/Fred Lee(LOS ANGELES) — The Voice coach Jennifer Hudson is Cosmopolitan‘s November cover star, and inside the pages of the magazine she gives one-word answers to describe a few of her former co-stars, like Beyoncé and Sex and the City actress Sarah Jessica Parker. JHud calls Bey “Sisterly” and Sarah “Genuine.” As for Adam Sandler and Empire‘s Taraji P. Henson, the former is is “Funny,” while Taraji is unmistakably Jennifer’s “Homegirl.”  The “Walk It Out” singer also dishes on another co-star — fellow Voice coach Blake Shelton — telling Cosmo that if given the chance to pick one of the show’s coaches to guide her, it would be “Blake, because we have the most similar taste in music.”As for JHud’s dream costar, she answers, “Jennifer Lawrence,” and adds that she’d love to guest-star on HBO’s “Insecure with Issa Rae.” To read more of Jennifer Hudson’s interview, pick up Cosmopolitan‘s November issue, which hits newsstands Tuesday, October 10.Copyright © 2017, ABC Radio. All rights reserved.Powered by WPeMatico Relatedlast_img read more

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Spring flowers are here at Mill Creek Lumber!

first_imgSPRING FLOWERS ARE HERE!  – MILL CREEK LUMBER, 623 E 16th St, Wellington (620-326-2083)Mill Creek Lumber has received their first plant order!!They have several hanging baskets, planters and 4″ vegetable plants to choose from.Great addition to any Easter decor.MANY MORE TO COME IN THE NEXT COUPLE OF WEEKS.last_img

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