Babies’ brain signals offer window into treating their pain

first_img Babies cry. They cry when they’re hungry, when they’re tired, when they need a diaper change — and when they’re in pain. For doctors, this is a problem. Could a baby’s cry mean an anesthetic isn’t working well during a procedure? That a painkiller for postoperative pain has worn off? Or could it mean something else entirely?Scientists at the University of Oxford think they have found a new way around that problem. Neuroscientist Caroline Hartley and her colleagues studied 72 infants undergoing medically necessary painful procedures, like a needle prick for a blood test. They found, using electrodes on the babies’ scalps, a signature change in brain activity about a half-second after a painful stimulus. In the future, that measure could help pain researchers objectively establish if an infant is in pain and, ultimately, determine how to manage it. The study was published in Science Translational Medicine on Wednesday.Other indicators are currently used to gauge an infant’s pain, like heart rate, oxygen saturation levels, and facial expression. Doctors should still use these indicators when they examine individual patients, Hartley noted, because they’re easy to assess in a clinical setting. But an EEG signature could be more specific than those and less likely to be triggered by other stressful, non-painful events.advertisement Giving newborns medicine is a dangerous guessing game. Can we make it safer? PHILIPPE HUGUEN/AFP/Getty Images Tags neurosciencepainpediatricsresearch That test was revised in 2014 by Bonnie Stevens, a professor at the University of Toronto and a senior scientists at the Hospital for Sick Children. Stevens, who was not involved in the EEG research, said the research was “exciting.”“I think it’s really moving the science of pain assessment in babies forward,” Stevens said. However, she added, “I don’t think looking at EEG responses is going to replace everything else.”Stevens agreed with the authors of the paper that an EEG is a specialized measurement best suited for research. (Determining medication dosages for infants is an area that needs more research — not just for pain medication, but for many other kinds.) She also noted that the researchers validated their results with only a part of the revised PIPP test and could have observed the EEG signals for a longer window to match the time it takes to see a behavioral response. Hartley acknowledged the study had other limitations, too. The study included 12 babies who were born after 34 weeks but before a full 40-week gestational period — but babies born even earlier than 34 weeks have different brain activity patterns, so the test wouldn’t be usable for them. The accuracy of the test is not great on an individual level; it could only accurately detect an infant in pain 64 percent of the time and was able to identify an infant not in pain 65 percent of the time.“We think that further research is needed before you could use it [on an individual basis],” Hartley said. However, it does a better job of determining across a group of infants if a painkiller is working as it should. In one of the team’s experiments, 11 out of 12 infants had a decreased pain-related EEG signal after doctors applied a topical anesthetic to their feet.Ultimately, an EEG could be a new, potentially valuable tool for pain researchers, Stevens said.“At the end of the day, we are going to need a multi-modal pain assessment for babies that is going to include both behavioral and physiological [measures] as well as something like EEG, which will pull everything together to give us a comprehensive pain assessment in babies.” Kate Sheridan This new EEG assessment will be one of two ways Hartley and her colleagues measure pain in their trial, in addition to a test based on an infant’s behavior, the revised Premature Infant Pain Profile.advertisement [email protected] Related:center_img 6 surprising facts about sugar-laden, virus-fighting breast milk @sheridan_kate By Kate Sheridan May 3, 2017 Reprints In the LabBabies’ brain signals offer window into treating their pain General Assignment Reporter Kate covers biotech startups and the venture capital firms that back them. And the approach is about to get its first field test. Hartley and another one of her coauthors have started recruiting patients for what is expected to be a three-year clinical trial to test the efficacy of morphine in infants. Treating an infant in pain is not like treating a tiny adult: Infants’ skins and intestines absorb drugs differently, and they can have different levels of enzymes that break down drugs and the receptors to which drugs bind, too. Related: About the Author Reprintslast_img read more

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FLU NEWS SCAN: Pandemic vaccine uptake, vaccine doses pulled, virus-related patents

first_imgApr 4, 2011Pandemic vaccine coverage in Germany was lowGerman uptake of the 2009 H1N1 vaccine was low in people older than 14, standing at about 8% for the general population and at almost 13% in healthcare workers and those with underlying medical conditions. Researchers reported their findings in an Apr 2 online article in Vaccine. They based their study on 13 telephone surveys that were conducted between November 2009 and April 2010. During the pandemic the German government purchased an adjuvanted monovalent vaccine (Pandremix, made by GlaxoSmithKline) for high-risk groups and the general public and an unadjuvanted vaccine made by CSL for pregnant women. They found that people who received seasonal flu immunizations were more likely to receive the pandemic vaccine. The authors concluded that pandemic vaccine uptake was low when compared with that in some other industrialized countries. For example, the coverage for healthcare workers was about 37% in the United States and 85% in the Netherlands. The researchers concluded that the low pandemic vaccination rates are a concern, particularly for at-risk groups, and signal the need to improve future pandemic vaccination and communication strategies.Apr 2 Vaccine abstractWHO details virus-related patents in pandemic preparedness reportThe World Health Organization (WHO) on Apr 1 released a report compiled by the World Intellectual Property Organization (WIPO), another United Nations agency, on flu pandemic preparedness patents and patent applications. The report’s purpose is to assist the WHO’s virus-sharing working group, which over the past several years has been grappling with how to assure that developing countries that share influenza viruses with the international research community and pharmaceutical industry benefit from the resulting vaccines, medications, and diagnostic tests. The WIPO report covers patents related to the H5N1 avian influenza virus and the 2009 H1N1 virus. The group identified 27 “patent families” clearly relevant to H5N1 and four patent families relevant to H1N1, all of them involving viral components or derivatives thereof. The authors found 35 more H5N1 and eight more H1N1 patent families that may be relevant. Of the patents that were relevant, 73% were vaccines, 24% were diagnostics, and 3% were therapeutics. None of the patents consisted of a sole element, such as a native virus. They also identified some patents that included known viral sequences. They found a number of patents from developed-world companies that are now co-owned by companies in developing countries, which they said could be an emerging model for ensuring broader access to new technology. The WHO’s virus-sharing working group is slated to report on its latest developments at the World Health Assembly, scheduled for May 16 to 24 in Geneva.Apr 1 WHO/WIPO pandemic influenza patent reportNarcolepsy concern prompts Ireland to pull remaining Pandemrix dosesIreland’s health ministry has decided to pull all remaining supplies of Pandemrix, the monovalent pandemic H1N1 vaccine, from general practitioner (GP) offices because of the suspected link to narcolepsy cases, the Independent newspaper reported yesterday. Eight narcolepsy cases have been reported in Pandemrix recipients in Ireland, most of them in young people. An increased risk of narcolepsy has also been reported in vaccinees in Finland and Sweden. Dr. Kevin Kelleher of the Irish Health Service Executive advised physicians in January not to use Pandemrix unless there was a shortage of seasonal flu vaccine (which contains the 2009 H1N1 strain). In a recent letter, Kelleher told physicians that remaining supplies of Pandemrix would be picked up from GP sites in the next few weeks, the newspaper reported. He said there has been no need to use the monovalent vaccine because extra supplies of seasonal vaccine were delivered.Apr 3 Independent storylast_img read more

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Jamaica’s Ardenne High School participates in United Nations UFUNA Model Assembly

first_imgL-R Hugh Billings, Jonell Campbell, Tresecka Campbell-Dawes, (staff member), Sarah-Lee Tucker, Chelsi-Rae Buckley, Nadine Molloy (principal) and Christian Allen. Students from Jamaica’s Ardenne High School were recently in New York City to participate in the United Nations UFUNA Model Assembly. The program offers students the opportunity to learn about the United Nations by simulating UN committees and roleplaying delegates.While in New York, Finn Partners, the Jamaica Tourist Board agency of record, donated its office space to hold a welcome reception for the team.last_img read more

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Bristol Sport TV – Featuring Korey Smith

first_imgAlso on this week’s show:Highlights and reaction from Bristol Rugby’s 16-21 victory over London ScottishBristol Flyers fool fans into thinking Bristol City defender Aden Flint had signed for the club on April Fools’ day.Dino Zamparelli reflects on a win and another podium finish in the 2016 Porsche Carrera Cup opening round at Brands HatchThere’s an exclusive interview with Jack Taylor of Gloucestershire Cricket who discusses plans for the season aheadAn update on the latest Ashton Gate Stadium redevelopment, as seating installation begins on the upper tier of the West StandNever miss another episode, click here to subscribe to Bristol Sport TV on YouTube.last_img read more

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Hamilton wins in Brazil as Mercedes take fifth F1 title

first_imgSAO PAULO,  (Reuters) – A lucky Lewis Hamilton won a tense Brazilian Grand Prix yesterday as his Mercedes team clinched the constructors’ title for the fifth year in a row and Max Verstappen raged at a lost opportunity. The win was the 72nd of Hamilton’s stellar career and 10th of a season that has already seen the 33-year-old Briton clinch his fifth championship, delivering Mercedes their fifth successive double.Hamilton had started on pole position but could not hold off Red Bull’s Verstappen, who led until a collision with Force India backmarker Esteban Ocon on the 44th of 71 laps sent the Dutchman into a spin and put the Mercedes driver back in front.A seething and swearing Verstappen battled back but could not close the gap, finishing runner-up 1.469 seconds adrift of Hamilton, who had never previously won in a season where he has taken the title with races to spare. Verstappen then took matters into his own hands in an angry post-race confrontation with Ocon that led to both being summoned by stewards.Ferrari’s veteran Kimi Raikkonen held off Red Bull’s Daniel Ricciardo to complete the podium on his 150th start for the Italian team.Ferrari had to score 13 points more than Mercedes to keep their hopes alive until Abu Dhabi at the end of the month but failed, with Sebastian Vettel finishing only sixth and behind Mercedes’ Valtteri Bottas in fifth. Mercedes now have 620 points with Ferrari on 553 and 43 still to be won.“That’s it. That’s the double, mate. MercedesAMG are the world champs,” Hamilton was told as he took the chequered flag at Interlagos after a race fraught with concerns about his tyres and engine.“It’s been an incredible journey with them. This is what everyone worked for, for the whole year,” said the ecstatic champion as the celebrations started with one race to go. “I’ve always told you how much of an honour it is to drive for them. Today was the best style that we could do it because we were struggling, we had problems to the end. We were a sitting duck at one stage.”Only the sport’s oldest and most successful team Ferrari have previously managed to win five championships in a row, taking six in succession during their golden Michael Schumacher era from 1999 to 2004.“It was a very difficult season, we had up and downs. Ferrari came back very strong and Red Bull at the end but that makes the championship victory even more enjoyable,” said team boss Toto Wolff. Verstappen, winner in Mexico two weeks ago, joined Hamilton on the podium but the Dutchman knew he should have been on the top step.The collision was the talking point of the day, with arguments on both sides.Ocon was handed a 10-second stop-and-go penalty for causing it but that came as no consolation for Verstappen, whose colourful language over the radio was largely bleeped out for television viewers.When the Dutchman found Ocon, at the post-race scales, matters became more physical with the Red Bull driver caught on television confronting the young Frenchman and giving him a shove. “You do everything well, you go through the field, we had a great car and then by such an idiot you get taken out while he’s being lapped. I have no words,” said Verstappen.“You can easily say afterwards that I have much more to lose than him but I’m just trying to do my race. Suddenly, a backmarker is trying to race you and taking a stupid risk to dive inside. What can I do about it?“The penalty for me is that I lost the victory but hopefully in 15 years’ time we can laugh about it.” Sauber’s Ferrari-bound rookie Charles Leclerc was ‘best of the rest’, the Monegasque finishing seventh after running as high as fourth during the pitstops.Haas savoured a double points finish to close on fourth-placed Renault, with Romain Grosjean eighth and Danish team mate Kevin Magnussen ninth.Ocon’s Mexican team mate Sergio Perez took the final point for a team that had hoped for much more.last_img read more

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Cloud Computing: Nearly One Third of IT Infrastructure Spending is Going to the Cloud

first_imgSpending on cloud infrastructure now makes up 30 percent of total IT infrastructure according to IDC.  The estimate is based on numbers from first quarter 2015 and is a jump from 26.4 percent in first quarter 2014.Kuba Stolarski, Research Manager at IDC, said that “Cloud IT infrastructure growth continues to outpace the growth of the overall IT infrastructure market, driven by the transition of workloads onto cloud-based platforms.  Both private and public cloud infrastructures have been growing at a similar pace, suggesting that customers are open to a broad array of hybrid deployment scenarios as they modernize their IT for the 3rd Platform, begin to deploy next-gen software solutions, and embrace modern management processes that enable agile, flexible, and extensible cloud platforms.”The market standing among cloud infrastructure vendors is:HP – 15.7 percent market shareDell – 11.9 percent shareCisco – 9.3 percent sharelast_img read more

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3 Innovations Coming to Mobile in 2015

first_imgThere are a number of innovations in business mobileOpens in a new window debuting from Intel and mobile device manufacturers in 2015. These will help enterprises to improve the user experience and productivity of their mobile work forces, and help IT bridge the gap between new user demands and the mobile equipment they offer.Form factor innovationThe forthcoming low-power, high-performance Intel Core M processor will enable form factor innovations such as razor-thin tablets that can offer the performance of a PC. Ultra-thin 2 in 1s are also going to be attractive to businesses who will be able to offer smaller and better form factors to their mobile workers and business travellers. These form factors will bridge the gap between new user demandsOpens in a new window for business client devices, and what the business can offer. The new super-thin tablets and notebooks will offer improvements in user experience, collaboration, productivity and portability.No wires technologyThe second innovation coming to mobiles is ‘no wires’ technology, which will simplify life for everyone. It will be a boon for mobile workers and IT departments, and continue the trend of workplace transformation. No wires docking, through Intel WiGig-based Wireless Docking technology, will transform meeting rooms. It gives workers ‘walk up’ convenience as it remembers their preferences, making them instantly productive. No wires docking can be used in combination with wire-free keyboards, mice, printers and monitors – such as the Intel Pro Wireless Display – and is poised to improve office working and modernise both consumer and business computing. Another exciting development coming in the future is ‘no wires charging’ for mobile devices. This will enable mobile workers to lay their device down on the desk so it can be charged automatically.This technology will accompany existing enterprise-class technology such as Intel vPro, which provides securityOpens in a new window and manageability to wire-free environments. Intel vPro can make wire-free meeting rooms secure, offer remote management and features such as transferring screens from one room to another to enhance collaboration.Stronger, simpler securityThirdly, more advanced security – which is simpler both to use and administer – is coming to mobile devices. New security innovations will simplify the sign-on process, and reduce the number of passwords required.Mobile devices will increasingly use multi-factor authentication, particularly biometric data such as face recognition, to improve business securityOpens in a new window. This ‘no passwords’ approach will simplify life for end-users, who will be able to unify their passwords by replacing them with a single biometric input instead.As for IT departments, multi-factor authentication will harden the security of the platform, and will also simplify security management.It will mean single sign-on for multiple cloud services through face recognition or two-factor authentication, and will utilise existing manageability and security features offered by Intel vPro technology.Mobile computing is about to enter a new phase of sophistication.- Ariflast_img read more

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Probable line-ups: Roma v Napoli

first_img Watch Serie A live in the UK on Premier Sports for just £11.99 per month including live LaLiga, Eredivisie, Scottish Cup Football and more. Visit: https://subscribe.premiersports.tv/ Roma could give Mert Cetin his first start as they host Napoli at the Stadio Olimpico, while doubts remain on the visiting front pair. It kicks off at 14.00 GMT, click here for a match preview. There is only one point separating the two sides going into the weekend, with Napoli drawing 2-2 in the controversial game against Atalanta and Roma putting four past Udinese. Federico Fazio is suspended due to his red card in Udine, he joins the lengthy list of absentees from the squad, which include the injured Lorenzo Pellegrini, Bryan Cristante, Amadou Diawara, Nikola Kalinic, Henrik Mkhitaryan and Davide Zappacosta. It means Mert Cetin could be in with a chance of making his full debut for the Giallorossi at the centre of defence. Gianluca Mancini will continue to deputise in central midfield. Edin Dzeko will lead the line, with Justin Kluivert, Javier Pastore and Nicolo Zaniolo expected to be playing just behind the Bosnian. Napoli meanwhile will be without coach Carlo Ancelotti, who was sent off in the draw against La Dea on Wednesday.  Right-back Kevin Malcuit is out for six months following knee surgery, midfielder Allan is also out for four weeks with a sprained knee. The good news is that former defender Kostas Manolas has returned to face his former club, whilst Mario Rui is also expected to return. Elseid Hysaj is struggling with a fratured sternum. Piotr Zielinski is expected to replace Allan in midfield, with Polish striker Arkadiusz Milik and Dries Mertens set to play up front, with Lorenzo Insigne and Jose Callejon on the wings. Mertens has a great record against Roma, scoring five goals from his last five games. However, there are mixed reports on who will lead the line this afternoon, as Hirving Lozano is also in with a shout. Roma: Pau Lopez; Spinazzola, Cetin, Smalling, Kolarov; Veretout, Mancini; Kluivert, Pastore, Zaniolo; Dzeko Napoli: Meret; Di Lorenzo, Manolas, Koulibaly, Mario Rui; Callejon, Zielinski, Fabian Ruiz, Insigne; Milik, Mertens Ref: Rocchilast_img read more

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Power outage stalls downtown CTrain

first_imgHope you made it in to work okay. FYI, the loss of power to the LRT was not caused by ENMAX but we’re helping get the lines running again.— ENMAX (@ENMAX) September 21, 2017 City of Calgary CTrains ground to a halt Thursday morning, due to a power outage. Major delays on the Red and Blue Lines left commuters in panic, and many late for work.The trains were finally back up and running at around 11:40 a.m., with Enmax saying the issue was caused by a train on 7th Avenue.CTrains on the #RedLine and #BlueLine are running through the core now and the power has been restored. #CTRiders pic.twitter.com/HNCZVKBMyp— Calgary Transit (@calgarytransit) September 21, 2017Shuttles were put in place for the several hours the trains were down, but still the delays caused headaches for many Calgarians, who vented on social media.I literally can’t get to work.— Sasha Spencer (@SashaSpencer09) September 21, 2017 Totally understand about the power. Bus drivers were confused and almost every passenger was confused. Communication needs to be better ??????— Just a Bee (@Mrsbell2008) September 21, 2017 @calgarytransit the time on your app are a out of sync. Or at least for route 5, haven’t checked any other. #yyc #transit— Karl Ove Sonnichsen (@WhiteWolf_yyc) September 21, 2017 I didn’t know it is walk to work day today ??????— yycwanderer (@startupdba) September 21, 2017last_img read more

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Tommy Lake Fire now 40 percent contained

first_imgFORT ST. JOHN, B.C. – The Tommy Lakes Wildfire is now 40 percent contained.  According to the B.C. Wildfire Service, the fire is now 22,000 hectares and did receive some rain on Saturday.The cooler temperatures and decreased wind, have enabled firefighters to get the upper hand and contain the fire.There are 234 firefighters building and reinforcing guard working to increase containment supported by 8 helicopters along with 22 pieces of heavy equipment. More informationOn May 27, 2018, an Area Restriction Order was put in place for Crown Land in the vicinity of the Tommy Lakes wildfire. This restricts public access to the active wildfire area and access roads within the Tommy Lakes wildfire boundary and surrounding area. For more information regarding the restricted area please refer to the attached order and map.The public is asked to respect this order to ensure your safety as well as the crews working on the Tommy Lakes wildfire. Public and crew safety is the number one priority of the BC Wildfire Service.Cause: Lightning Lightning CausedResources• 234 firefighters• 8 helicopters• 22 heavy equipmentThe decrease in area to 22,000ha is due to more accurate mapping.Today (June 3rd),there was no growth on the Tommy Lakes wildfire and some sections of the fire did receive rain. The cooler temperatures and higher relative humidity continue to aid fire suppression efforts. The crews have made great progress to date and the fire is currently 40% contained.Today, there are 234 firefighters building and reinforcing guard working to increase containment supported by 8 helicopters along with 22 pieces of heavy equipment.The primary objectives are to establish machine guard and if conditions permit conduct controlled burning operations, in order to protect oil and gas infrastructure, communities and other values in the vicinity of G80340.On the northwest side of the fire, crews along with heavy equipment are working to complete the guard on the west side of the Beatton River. Crews are also working on a contingency guard along the western flank.On the southwest flank, crews are mopping up hot spots from 6 km east on the South Nig, and well site 74 off Beatton road.On the east flank, crews are working to complete mop-up and patrols along and in the vicinity of the North Nig road. They are also mopping up east of the Beatton Road and continue with direct attack west of the 71km mark on the Beatton Road. Crews are also working to complete mop-up from the North Nig road working south towards the 76km mark on the Beatton Road.On the northeast flank, crews continue to patrol and mop-up guards and hose trails constructed off the North Nig and Tommy Lakes roads, and complete the Wellsite access road at 74 km. They are working to construct new guard and support mop up along pipeline guard with crews in the southwest.In the vicinity of the fire, smoke may be visible to the public.The Tommy Lakes (G80340) is the result of the amalgamation of the former Beatton Lake (G80340) and the Tommy Lakes Road (G80341). This amalgamation occurred on May 25, 2018. The Peace River Regional District removed the evacuation alert for a small farming community near the fire Friday.Here is the full update from the B.C. Wildfire Service:Tommy Lakes (G80340)Last updated: Sunday, June 03, 2018 at 10:18 AMLocation: Approximately 29km northeast of mile 109 Hwy 97 (Alaska Highway)• See approximate location of this wildfire on an See Map interactive map• View an interactive map of all active Wildfires of Note.Discovered: Tuesday, May 22, 2018Size: 22,000.0 hectarescenter_img Status: Active• 40% containedInterface: Interface Interface FirePrevious evacuations have been rescinded.As of 1615 on June 1,2018, the Peace River Regional District rescinded the Evacuation Alert for Electoral Area B.last_img read more

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