Assassin’s Creed Odyssey: Critical Consensus

first_imgAssassin’s Creed Odyssey: Critical ConsensusReviewers praise Ubisoft’s latest as a series high, thanks to an engaging world and the completed shift to an RPG structureJames BatchelorEditor-in-ChiefWednesday 3rd October 2018Share this article Recommend Tweet ShareCompanies in this articleUbisoftUbisoft Quebec City”Ubisoft really wasn’t joking around when it called the latest Assassin’s Creed game an Odyssey,” begins GamesRadar+’s Sam Loveridge in her five out of five review. “It’s not just in the Greek tragedy-inspired story, the vast, vast map or the sheer number of hours you’re going to sink into it. It’s the journey. The journey from one Greek island to another, with dolphins and whales cresting the waves alongside your boat. It’s about the journey across the stunning Grecian landscape, ranging from forests bearing autumnal hues, to the majestic white marble buildings nestled comfortably in the cities, and absolutely everything in between. Including an active volcano that you can swan dive into. But more importantly, it’s also about the journey to discover who exactly you are in Assassin’s Creed Odyssey.”The search for identity is a somewhat fitting theme as this is Ubisoft’s greatest departure from the series formula to date. Building on the open-world structure of last year’s Origins, Odyssey adds a dialogue system, romances, multiple endings and even more RPG mechanics. In fact, Twinfinite’s Zhiqing Wan says it “barely even feels like an Assassin’s Creed game” and stands up just as well as a “really strong, standalone historical fiction video game.””It’s vast, there’s no getting around that, but optional goat-hunting bounties aside the majority of your time with Odyssey is well respected” Tom Phillips, EurogamerEurogamer’s Tom Phillips notes that even the franchise’s traditional focus on historical events has “shifted effortlessly into a place where godlike powers and mythical artefacts are now a major part of its everyday parlance”. In addition to soldiers and members of a sinister cult, players find themselves facing off against mythological creatures like Medusa – all tied to the First Civilization revealed in earlier games – while wielding powers like teleportation and a supernatural weapon in the Spear of Leonidas.”The blade symbolises the shift away from Ubisoft’s habitual Assassin’s Creed gameplay to one that feels freer, more fantastical and more fun,” Phillips writes in his Recommended review. “Why wait to dual assassinate a pair of enemies who’ve finally rotated around their guard patterns to stand next to one another when you can blink around a map chaining assassinations over great distances, should you have invested in the skills and built-up the stamina to do so?”US Gamer’s Mike Williams agrees, adding: “Assassin’s Creed: Odyssey is a convergence of some different concepts for the franchise. The core of it is undeniably built upon the same foundation as Origins. If you’ve played Origins, combat and the general gameplay loop feel largely the same. If you’re not heavily into Assassin’s Creed, I’d either put some space between playing Origins and Odyssey, or jump straight into the latter game.”Much has been written about the size of the game and it’s Grecian world, considerably larger than the already expansive Ancient Egypt of Origins. Phillips admits he was “wary Odyssey would begin to feel bloated”, but reports that’s not the case. “Kassandra is pretty cheeky by nature, and isn’t afraid to taunt her foes in the most demeaning ways. Like, say, stealing their fake eye and stuffing it up a goat’s ass in front of them” Zhiqing Wan, Twinfinite”It’s vast, there’s no getting around that, but optional goat-hunting bounties aside the majority of your time with Odyssey is well respected,” he says. “You’re always a few hundred XP off a new level and new skill, or a mission away from completing an island’s questline, or one Cultist kill behind upgrading my spear… Odyssey is an enormous game – certainly one of the biggest, if not the biggest game Ubisoft has ever made. It’s an astonishing creation, extraordinarily generous and solidly crafted, and like its namesake is something that will live long in the telling.”VG247’s James Billcliffe concurs, describing Odyssey as “easily the biggest Assassin’s Creed there’s ever been” but notes that even after 40 hours of gameplay, “it’s never been boring.”This might partly be attributable to the engaging and well-performed main leads – with particular praise going to Kassandra – and the more light-hearted attitude your chosen Spartan takes to their adventure.”The Assassin’s Creed franchise has always been very self-serious, even with the more laid-back assassins like Ezio and Jacob Frye,” Wan observes. “With Odyssey, however, Ubisoft isn’t afraid to sprinkle a little humor into virtually every aspect of the game. Kassandra (or Alexios) is pretty cheeky by nature, and isn’t afraid to taunt her foes in the most demeaning ways. Like, say, stealing their fake eye and stuffing it up a goat’s ass in front of them.”While it’s hard to compare to its own predecessors, Assassin’s Creed Odyssey has been positioned as a contender to CD Projekt’s most famous RPG.”This is easily an experience of The Witcher 3 proportions, and while I can sympathise with someone who wants to see Odyssey’s main family storyline wrapped up in 20 hours, this is simply not that kind of game,” writes Phillips. “When Assassin’s Creed Odyssey is on point, you can tell that Ubisoft was looking at CD Projekt Red’s The Witcher for inspiration. What you do in the quests isn’t particularly novel, but the folks you meet are” Mike Williams, USGamerWilliams adds: “When Assassin’s Creed Odyssey is on point, you can tell that Ubisoft was looking at CD Projekt Red’s The Witcher for inspiration. What you do in the quests isn’t particularly novel, but the folks you meet are. “One lady wants you to collect the ingredients to make a potion to increase her husband’s stamina so they can have more sex. Another man has trapped himself in jail at the protests of his parents, because a prophecy said he’d do them harm with his sword and shield. I won’t spoil all the ways that one can go, but some are truly weird. On a random island, I saved a hopelessly stupid captain from his crew, who were about to kill him for getting them shipwrecked. The main plot is relayed seriously, but when Odyssey gets weird, it also gets better.”Billcliffe also draws this comparison, reiterating that side quests are more likely to throw up “quirky stories with fun and memorable characters” than the “filler from older [AC] games”. Improved combat and a rewarding loot system help engage players with these additional missions, but even without these mechanics, there is a lot of praise for the accompanying stories Ubisoft is trying to tell.”In the moment to moment there’s a richness and a warmth in the dialogue that I’ve never seen before in a Assassin’s Creed game,” says Loveridge. “Although I adore Assassin’s Creed Origins and its protagonists, Bayek and Aya, the side quests could feel a little cookie cutter at times – go here, do this, fight that thing. They were certainly a huge step up from Assassin’s Creed games of yore, but Odyssey is a giant leap from anything to date. “I’ve never seen a game blur the line between side quest and story mission so much as Odyssey does, because all its many (many, many) quest types are delivered with the same gravitas and polish. It’s sometimes actually difficult to figure out whether you’ve stumbled upon a particularly lengthy sidequest or following a main story arc.”Wan agrees: “There’s a very strong sense of satisfaction to be had from following a random side quest that you thought would just be good for experience points, then finding out that it actually leads you to yet another vicious operation being handled by a cult member. “No-one’s made an open-world RPG with this much depth and brilliance since The Witcher 3. This really is the ultimate Creed” Sam Loveridge, GamesRadar+”Ubisoft has done a wonderful job of putting these cult members everywhere in the game, making them feel truly insidious, sinister, and like they’ve really got their eyes and ears everywhere. The Legendary gear that drops from the cultists certainly makes the hunt worth the effort, too.”Additionally, the introduction of choice – not just in how you tackle each situation but even the dialogue and ways you interact with characters – has been praised as a game-changer for the often heavily scripted Assassin’s Creed series. It certainly helps to draw players further into the main quest, according to Williams.”I wouldn’t say the story is far better than Origins, but the weight of your choices lends it more impact overall,” he writes. “When one supporting cast member dies, I wondered if my actions earlier in the game could’ve saved them; it’s entirely possible they always die, but I felt guilty because in my head, there was a reality where I could’ve saved them. “Assassin’s Creed Odyssey even has multiple endings depending on some of the choices made, of which I’ve only seen a few. It’s a good direction for the series, though I wish more of the interesting choices found their way down to some of the more boilerplate quests, because you’ll be doing a lot of them.”Wan warns that Odyssey’s quest choices “might seem tacked on and very straightforward at first glance” but this improved over the course of the game: “I got to see more possible combinations and permutations of different scenarios that could’ve played out instead of the one I got. The game’s branches get pretty staggering later on, and Ubisoft definitely did an excellent job with those story deviations on their first go.”With a metacritic score of 85, it’s no surprise that most reviews for Ubisoft’s epic are glowing. Shifting a typically action-centric series further into RPG territory was a gamble but, critically at least, it appears to have paid off. Related JobsSenior Game Designer – UE4 – AAA United Kingdom Amiqus GamesProgrammer – REMOTE – work with industry veterans! North West Amiqus GamesJunior Video Editor – GLOBAL publisher United Kingdom Amiqus GamesDiscover more jobs in games “Odyssey and Origins aren’t the Assassin’s Creeds of old, but they’re both a compelling new foundation for the franchise and Odyssey is clearly a step in the right direction,” says Williams. Loveridge concludes: “In the end this journey is all about choice. The people you decide to let live, the romances you have, the sexuality lines you blur, the questlines you follow, the people you help and hinder and the RPG picks you make. It’s an utterly beautifully crafted world and story, with cutscenes for literally days. “After 70 hours I’ve only just finished the main storyline and I still have plenty to see in Odyssey’s Greece, and it’s a joy to keep on exploring. No-one’s made an open-world RPG with this much depth and brilliance since The Witcher 3. This really is the ultimate Creed.”Celebrating employer excellence in the video games industry8th July 2021Submit your company Sign up for The Publishing & Retail newsletter and get the best of GamesIndustry.biz in your inbox. Enter your email addressMore storiesUbisoft posts record sales yet again, delays Skull & Bones yet againPublisher moves away from target of 3-4 premium AAA titles a year, wants to build free-to-play “to be trending toward AAA ambitions over the long term”By Brendan Sinclair 7 hours agoFirst-party Ubisoft titles will now be branded as ”Ubisoft Originals”Change was made alongside the announcement of new Tom Clancy titleBy Danielle Partis 2 days agoLatest comments Sign in to contributeEmail addressPasswordSign in Need an account? Register now.last_img read more

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When Gate-keepers become the Advocates of Gate-breakers

first_imgJaya Bachchan’s statement in the Rajya Sabha on September 15, 2020, is at odds with and do not reflect the reality of today’s Bollywood which now is much different than what it used to be in Jaya’s heydays when she acted in films as a young actor.The hair on her head was jet black at that time but now they have grown fully grey. Much water has flown in the Ganges below the bridge since she acted in films in her prime youth. The Ganges of Bollywood is no longer the Ganges of early Sixties or Seventies. It is a dirty river (rather a ‘ganda nala’) where vices like drug-taking, malafide insider vs. outsider considerations, casting couch, sexual exploitation of young aspiring girls joining the world of glamour, award fixing, nepotism, etc., have gripped the industry.With what purpose Jaya Bachchan (whom I greatly admired for her charm and brilliant acting in films) has said all this? Who is she trying to defend and whom is she targeting? She ought to realize that the healthy survival of the film industry today is at stake. The film industry is not a holy cow that it cannot be touched. Kangana Ranaut has drawn the attention of the people in general against the malaise of drugs, etc that is widely prevalent in the Indian film industry and also toward the bias and vindictiveness of a Government, the political party and the (un)civic bodies which act at the behest of the political bosses, causing discriminatory, unjustified and immense damage/harm to an individual and his/her property (and that too when the incumbent is out of the station and hence not present).Jaya’s remarks: “kuchh log jis thali mein khate hain, usi  thali mein ched karte hain” are, unfortunately, misplaced and out of point. First of all, the film industry as a whole is not a company or employer of Kangana, it is a pluralistic entity. Other than some who are born with a silver spoon in their mouths, the rest have to work hard to make their own thalis’.So, her remarks are misconceived and not appropriate. Kangana has made her place in the film world by dint of her hard work and talent. She is a bold, courageous woman of substance who has earned a respectful place in Bollywood. Second, there can be no cleansing of an entity, organization or industry unless there are some brave hearts as whistleblowers who act as catalysts for cleansing the rot that has set in the industry at such a scale that it cannot be left to chance or heavenly intervention. The case of Sushant Singh Rajput, the burly talented young actor of promise who became a victim of Industry’s drug conundrum is a case in point. Indian filmdom today stands at crossroads.The problem with some people is that they do not/cannot see the light of the day or dark of the night. Kangana, with her bold statements, in a sense, has acted as a whistleblower and has done a useful service to the film industry. She, in fact, should be lauded for her efforts and the sacrifice all that involves. When the veterans of the film industry who are supposed to be gatekeepers of healthy practices and values of the Indian cine-world become advocates of gate breakers, directly or indirectly, God knows what can happen.last_img read more

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SSCC athletes are Academic All-Americans

first_img Top Searches Top Searches VommoSchoolThat SSCC athletes are Academic All-AmericansMarch 8, 2016Peoples DefenderSports0 The Southern State Athletic Department is excited to announce that five players from the SSCC basketball programs have earned 2016 USCAA Basketball National All-Academic Team.During the championship banquet at Nemacolin Woodlands Resort on March 1, the USCAA announced the 2016 USCAA Basketball National All-Academic team.National All-Academic team honors are awarded to student-athletes of sophomore standing or higher with at least a 3.5 GPA.The Southern State Community College Athletes receiving this honor were:Ryan Inman – Sophomore from Lynchburg-Clay High School – Men’s BasketballNatasha Barr – Sophomore from West Union High School – Women’s BasketballSarah Rosselott – Sophomore from Lynchburg-Clay High School – Women’s BasketballTia Shepherd – Sophomore from Adams County Christian – Women’s BasketballJessica Solaro – Sophomore from Adams County Christian – Women’s Basketball PreviousCelebrating 50 years of marriageNextKids College coming April 2 Around the WebThis Video Will Soon Be Banned. Watch Before It’s DeletedSecrets RevealedMd: Do This Immediately if You Have Diabetes (Watch)Blood Sugar BlasterThis Weird Method Can Restore Your Vision Naturally (Watch)Healthier LivingHave an Enlarged Prostate? Urologist Reveals: Do This Immediately (Watch)Healthier LivingIf You Have Ringing Ears Do This Immediately (Ends Tinnitus)Healthier LivingWomen Only: Stretch This Muscle to Stop Bladder Leakage (Watch)Healthier LivingThe content you see here is paid for by the advertiser or content provider whose link you click on, and is recommended to you by Revcontent. As the leading platform for native advertising and content recommendation, Revcontent uses interest based targeting to select content that we think will be of particular interest to you. We encourage you to view your opt out options in Revcontent’s Privacy PolicyWant your content to appear on sites like this?Increase Your Engagement Now!Want to report this publisher’s content as misinformation?Submit a ReportGot it, thanks!Remove Content Link?Please choose a reason below:Fake NewsMisleadingNot InterestedOffensiveRepetitiveSubmitCancel HomeSportsSSCC athletes are Academic All-Americans – https://www.peoplesdefender.com/wp-content/uploads/2016/03/web1_Patriot.jpg Powered By 10 Sec Best Carrot Cake Ever NextStay Best Carrot Cake EverNOW PLAYINGMama’s Deviled EggsNOW PLAYINGApple Pie Bites With Caramel SauceNOW PLAYINGHawaiian Roll Ham SlidersNOW PLAYINGHomemade Caramel SauceNOW PLAYING5 Easy and Delicious Crock Pot Meatball Appetizer RecipesNOW PLAYINGApple Pie BitesNOW PLAYINGOld Fashioned Soft and Buttery Yeast RollsNOW PLAYINGCream Cheese Cake Mix CookiesNOW PLAYINGHow to Slice & Mince Vegetables Like a ProNOW PLAYINGPumpkin Cream Cheese BarsNOW PLAYINGHow to Knead DoughNOW PLAYINGHow to Use a Meat ThermometerNOW PLAYINGSlow Cooker/Crock Pot HintsNOW PLAYINGHow to Quarter a ChickenNOW PLAYINGHow to Clean Garbage DisposalsNOW PLAYINGHow to Clean Stainless Steel SinksNOW PLAYINGHow to Cook Scrambled EggsNOW PLAYINGHow to Peel Hard Boiled EggsNOW PLAYINGHow to Chill a Drink in 2 MinutesNOW PLAYINGHow to Chop an Onion PerfectlyNOW PLAYINGPerfect Bacon Every TimeNOW PLAYINGSweet Alabama PecanbreadNOW PLAYINGParmesan Baked Pork ChopsNOW PLAYINGPrime Rib Roast Au Jus Perfect Every Time! No FailNOW PLAYING Arrow Left #1 Icon Created with Sketch. Arrow right #1 Icon Created with Sketch. last_img read more

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Woman arrested for allegedly attacking 92-year-old man with a brick

first_imgKABC(LOS ANGELES) — A 92-year-old man was brutally attacked by a woman with a brick while walking down a Los Angeles street on July 4, police said.The Los Angeles County Sheriff’s Department said that a suspect in the attack, Laquisha Jones, 30, was arrested Tuesday in the incident.The victim was identified by police as Rodolfo Rodriguez. ABC-owned station KABC reported that a witness saw a woman “[push] him and dropped him. She took a block of concrete and hit him in his head many times.”Jones, 30, was charged with assault with a deadly weapon and is being held in lieu of $200,000 bail.The sheriff’s department said that the motive for the assault remains unknown.An eyewitness told KABC that the attack started after Rodriguez passed the woman while walking down the sidewalk.Rodriguez was taken to a local hospital for treatment but has since been released to recover from his injuries at home, according to police.“He is doing really bad, has a lot of bruises on his face and a broken cheekbone,” a man who says he is Rodriguez’s grandson wrote on a GoFundMe page created to collect funds for his medical expenses. The fundraiser had reached more than $250,000 by Wednesday.A court date has not yet been set for Jones, according to the Los Angeles County Sherriff’s Department database.Copyright © 2018, ABC Radio. All rights reserved.last_img read more

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Housing

first_imgMCAS New River has two housing areas, Peter Field Point and McCutcheon Manor.Applications for assignment to Marine Corps family housing (DD form 1746) should be completed and directed to the Family Housing Office on Tarawa Terrace, Building TT-43.Waiting times for government quarters vary from one to 18 months.The maintenance department is open 8 a.m. to 4 p.m. and can be reached at 877-509-2424 anytime regarding maintenance issues.For additional information, call 910-451-2895 or write to the Family Housing Division, Building TT-43, Tarawa Terrace, NC 28543.Bachelor Officer and Enlisted Quarters Quarters are available for single or unaccompanied officers and single or unaccompanied enlisted service members in the ranks E-6 and above. Call 910-449-6621 for more information. All service members E-5 and below must check in with their units or their duty officer. They will be directed to the Joint Reception Center, where they will have their orders stamped and will then be directed to their unit barracks. The JRC can be reached at 910-449-6554.last_img read more

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Bella Ciao’s New Urban Bike – The REPORTER

first_imgBello Ciao, makers of handcrafted Italian frames that are assembled in Germany, have added one more bike to their classic cycle lineup with the introduction of the REPORTER.  This lugged steel frame bike comes in either a single speed or Shimano Alfine 8 speed version, and is being billed as a lightweight urban ride.There are increasingly more single speed urban rides hitting the market these days.  All the major brands are on board, and a host of “direct to consumer” bikes have popped up.  Head on past the jump to find out how the REPORTER stacks up.In Bella Ciao’s Words:BELLA CIAO REPORTERThe sporty lightweight urban bike.The REPORTER is the classic Italian handmade enthusiast’s single speed machine. Extremely lightweight with excellent handling characteristics at high speed or through city rush hour traffic. Built with the very finest components and available in Single Speed or with the Shimano Alfine 8 speed gear option.SPECIFICATIONLugged Frame: Italian handmade double butted Columbus Cromo tubing.Frame sizes: 54*, 57, 60, 63* cm (*upon request)6-mm-thick horizontal dropoutsAnti-corrosion layer plus 2-layer powder coating paint.BELLA CIAO Componenti Speciali, hand polished aluminium straight bar.Headset Tange Seiki, polished aluminiumRacing Stem, polished aluminiumPolished aluminum wheels, 28 inch, double wall, eyelets, stainless 36/36 spokesMiche Primato hubsTyres Continental Sport Contact, Semi-Slicks, 32mmStronglight crankset, aluminum, polished (SS 50 x 18)Pedals MKS Sylvan Stream, polished aluminiumSeat post Miche Primato Skeleton, polished aluminiumSelle San Marco Regal – brown suede saddleTotal weight of bike: ca. 11kgPrices are £949 (single speed) and £1199 for the Alfine 8 speed version.For those playing the home game in the US, that translates to $1529.29 for the single speed, and $1932.16 for the Alfine version.  Also, that 11kg converts to about 24lbs.Available from www.bikesales4u.com At 11kg (24.2lbs), I am not sure I would describe the bike as “extremely lightweight.”  Maybe my definition of “lightweight” is a bit skewed after visiting the HetFairWheel Podium Gallery.  Otherwise, the parts build seems decent, and a lugged steel frame rolling on 32c tires sounds like a good plush ride to me.Information on the REPORTER over at Bella Ciao’s website is lacking at the moment.  But, if you do head that way, they have a few other rides worth looking at.last_img read more

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FairPoint buyer settles with Maine, NH; Vermont expected soon

first_imgVermont Business Magazine Regulators in Maine and New Hampshire reached settlements with Consolidated Communications this week that help clear the way for the FairPoint sale to Consolidated. The company is still meeting with regulators in Vermont, and a settlement is expected there soon, according to the IBEW union. FairPoint is Vermont’s largest telecom. Consolidated is expected to acquire FairPoint this quarter. FairPoint agreed to be acquired by Consolidated last December in an all-stock deal valued at about $1.5 billion (includes $887 million in debt).As part of the settlement with Maine’s Public Advocate, Consolidated has agreed to spend $17.4 million per year for calendar years 2018, 2019, and 2020 to grow and maintain the network in Maine.FairPoint sold to Consolidated in all-stock dealvermontbiz.comThe settlement with New Hampshire’s Consumer Advocate requires Consolidated to make capital expenditures on the network valued at 13 percent of in-state revenues per year for the years 2018, 2019, and 2020. In addition, in each of those years, they’ll spend an additional $1 million per year to address service quality issues, including high trouble report rates. Thirteen percent of revenues in New Hampshire represents an increase over FairPoint’s typical capital spending level for the past few years.The unions said in a statement that their intervention in the processes in Maine and New Hampshire helped to secure those spending commitments.”We are intervening in the process in Vermont as well, and expect the company will make similar commitments there. We applaud this as a positive step that will be good for both our members and consumers.”That said, we are deeply concerned about the company’s future staffing plans, in part because of its repeated references to “synergies.” In our experience, corporate talk of synergies often presages outsourcing of good local jobs. For now, our contract contains important job protections, and our unions will continue to vigorously defend them.”Our highest priority now is to prepare for bargaining in 2018, when we will fight for good jobs and quality service in Northern New England, just as we did in 2014 and 2015 when FairPoint attempted to outsource our jobs. We hope that Consolidated will choose another path, one of cooperation with and respect for the workers who have built and maintain the critical network that our customers depend on.”The International Brotherhood of Electrical Workers (IBEW) System Council T-9 represents nearly 1,500 employees at FairPoint Communications in Maine, New Hampshire, and Vermont. The Communications Workers of America (CWA) Local 1400 represents 200 FairPoint employees in the three states.Source: IBEW 5.24.2017last_img read more

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Northeast Johnson County morning roundup

first_imgSM East Makin’ Waves Swim Clinic set for Jan. 23. Up-and-coming swimmers will have a chance to learn from members of the 2015 6A State Champion boys swimming team from SM East later this month. The third annual Makin’ Waves Swim Clinic will be held this coming Saturday, Jan. 23 at the SM East pool. The clinic is open to boys and girls. The first session, from 10:30 a.m. to noon, will be for kids age 10 and younger. The second session, from noon to 1:30 p.m., will be for kids 11 and older. The cost is $25 per swimmer. You can download the registration flier for the event here.Saint Luke’s specialty clinic coming to Mission Farms. Construction is expected to start in February on a Saint Luke’s Health System clinic that will combine primary care physicians, an urgent care clinic, specialists, pharmacy and x-ray in the same location. [Saint Luke’s plans to put mixed-use clinic in luxury mixed-use development – Kansas City Business Journal]Roeland Park anti-discrimination battle recalled in interview. Elizabeth Andersen was a frequent speaker in favor of the anti-discrimination ordinance passed in Roeland Park after many discussions by the city council. The talks about what communities can learn from that experience in an interview with Camp, a publication for the Kansas City LGBT community. [The Camp 10 – Elizabeth Andersen]Northeast Johnson County morning roundup is brought to you by Twisted Sisters Coffee Shop on Johnson Drive. For updates on the latest blends and specialty drinks available, follow them on Facebook.last_img read more

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Team ends nonconference schedule with close loss

first_imgThe Gophers knotted the score in the bottom half of the frame on senior center fielder Troy Larson’s sacrifice fly.Milwaukee took advantage of a throwing error by junior first baseman Dan Olinger in the top of the seventh inning to score the decisive run.The Gophers loaded the bases with just one out in the bottom of the seventh, but freshman second baseman Connor Schaefbauer struck out, and senior catcher Kurt Schlangen flew out to end the threat.Several Major League Baseball scouts, including representatives from the Atlanta Braves and Cincinnati Reds, were on hand to watch Panthers closer Joshua Uhen.His fastball topped out at 96 mph, but he nearly blew the game on the wild pitch.Minnesota will conclude its season with home series against Big Ten opponents Nebraska and Illinois. Team ends nonconference schedule with close lossThe Gophers lost on a play at the plate in the last inning.Emily DunkerMinnesota infielder Troy Larson hits a foul ball Tuesday, March 12, 2013, at the Metrodome. Samuel GordonMay 9, 2013Jump to CommentsShare on FacebookShare on TwitterShare via EmailPrintFor the second time this season, the Gophers lost on a play at the plate.Minnesota junior shortstop Michael Handel was thrown out at the plate to end Minnesota’s 2-1 loss to Milwaukee on Wednesday at Siebert Field. He was attempting to score on a wild pitch.Wednesday’s game was Minnesota’s final nonconference tilt of the regular season. The Gophers finished that part of their schedule with a 17-12 record.Minnesota lost to Indiana State in similar fashion March 15.It wasn’t just the play at the plate that doomed the Gophers. Their bats were asleep for most of the afternoon.The Gophers hit the ball extremely well in their last two series, but they had just three hits Wednesday.Milwaukee took an early lead after starting the second inning with three straight singles off sophomore starter Ty McDevitt.last_img read more

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How to rule a gene galaxy: A lesson from developing neurons

first_img“Coherent regulation of multiple genes can pose substantial logistical problems, akin running a successful business employing thousands of people or controlling the vast Galactic Empire from the Star Wars movies” remarks Dr. Eugene Makeyev, a senior author of the study from the MRC CDN. “Our work suggests that fine-tuning messenger stability is an important mechanism orchestrating gene expression changes during normal brain development”.Defective regulation of messenger stability, cellular localization and translation into corresponding protein products often leads to serious medical conditions including neurodegenerative diseases and cancer. A subset of the TTP/miR-9 target genes have been previously linked to these disorders and it will be important to determine whether deregulation of TTP or/and miR-9 plays a causative role in such pathological contexts.Moreover, by uncovering a hitherto unknown mechanism mediating neuronal differentiation, the study by Makeyev and co-authors should facilitate development of novel cell replacement therapies for neurological and neurodegenerative diseases. “Natural renewal of neurons in the adult brain is notoriously inefficient and it likely becomes virtually non-existent as we grow older. With a continued increase in the average life expectancy neuron replacement might become a common medical procedure at some point in the future. Luke Skywalker and his aging father would certainly relate to this idea”. LinkedIn Email Share The human organism contains hundreds of distinct cell types that often differ from their neighbours in shape and function. To acquire and maintain its characteristic features, each cell type must express a unique subset of genes. Neurons, the functional units of our brain, develop through differentiation of neuronal precursors, a process that depends on coordinated activation of hundreds and possibly thousands of neuron-specific genes.A new study published in Nature Communications by researchers from the MRC Centre for Developmental Neurobiology (MRC CDN) at IoPPN, carried out in collaboration with the Tian lab at the Rutgers New Jersey Medical School (USA), unravels how this synchrony is achieved at the molecular level. The researchers found that many RNA messengers encoding neuronal proteins contain specialized sequences that can promote their destabilization in the presence of an RNA-binding protein called tristetraprolin, or TTP.This protein is expressed at relatively high levels in proliferating precursors and non-neuronal cells but down-regulated in developing neurons by a brain-enriched regulatory RNA called miR-9. The TTP/miR-9 pair functions as a switch limiting unscheduled accumulation of neuronal messengers in non-neuronal cells and ensuring coordinated accumulation of these molecules in neurons.center_img Share on Facebook Pinterest Share on Twitterlast_img read more

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